Syracuse Orange (13) at Louisville Cardinals (15) 12:00 PM ET

Syracuse heads into this game coming off a brutal loss against Georgetown on Wednesday. The Orange had a 53-49 lead with just over six minutes remaining but the Hoyas closed the game on a 15-3 run to hand Syracuse its fifth loss in seven games. It has lost three straight at home but it has won two in a row on the road including a big win at Connecticut two games back. The Orange are now 1-3 in their last four games against ranked teams and the Hoyas loss dropped them to 9-14 ATS on the season.

The Cardinals had a great chance for another road upset but they allowed the first 14 points in overtime and lost by 10. It was the second close call as they lost by three points at Georgetown which followed an overtime win at Connecticut. Louisville is 15-2 at home this season including a perfect 5-0 record in the Big East but three of the last four wins have come by four, one and one point. The Cardinals won both meetings with Syracuse last year and they are 4-0-1 ATS in the last five home meetings.

Kentucky Wildcats (18) at Vanderbilt Commodores (24) 1:00 PM ET

Kentucky was able to withstand a couple of runs from Tennessee as it spoiled the SEC debut of Bruce Pearl to improve to 5-4 in the SEC. The Wildcats still trail first place Florida by two games but they still have a game left against the Gators and four of their next five games after this one are at home. The win over Tennessee snapped a two-game slide for Kentucky with both of those losses coming by a bucket. The Wildcats are just 1-4 both straight up and against the number on the road in the SEC.

Vanderbilt has won two in a row after snapping its own two-game losing streak which included a surprising 11-point home loss against Arkansas, its first home loss of the season. Winning at Memorial Gym has been tough on the opposition as the Commodores are 74-10 at home since the 2006-07 season. They have won 11 of 13 games as a favorite this season including nine of 10 at home but that includes a 4-6 ATS mark and Vanderbilt is only 1-3 ATS as a chalk of seven or fewer points.

Ohio St. Buckeyes (1) at Wisconsin Badgers (14) 2:00 PM ET

This is a game that many have had circled as Ohio St.’s first loss this season and it will be no easy feat for the Buckeyes to remain undefeated. This is déjà vu all over again as it was less than four months ago that the Buckeyes came in with the number one football ranking and fell to Wisconsin. Ohio St. is 24-0 overall including 8-0 on the road and it had won four straight away from home by five points or fewer prior to its win on Sunday at Minnesota by 13 points. The Buckeyes are 9-3 ATS in their last 12 road games.

Wisconsin is coming off an overtime win at Iowa on Wednesday and it is certainly possible the Badgers were looking ahead to this one. Returning home definitely helps as they are 13-0 this season and Wisconsin has won 34 of its last 35 games at the Kohl Center, with Illinois being the only winner. This is the first time in six years that a number one team has come to Madison so the Kohl Center will be rocking. The Badgers are 6-2 ATS in their last eight home games against teams with a winning road record.

Pittsburgh Panthers (4) at Villanova Wildcats (10) 9:00 PM ET

After a home loss to Notre Dame, Pittsburgh has won three straight games including a five-point victory at West Virginia in the ‘Backyard Brawl’ on Monday. That improved the Panthers to 5-0 in true road games, all of which have been conference games. They will be playing its second straight game without leading scorer Ashton Gibbs and his absence was felt despite the win over the Mountaineers as the Panthers were just 1-6 from long range. Pittsburgh is 6-1 ATS in its last seven games following a win.

The Wildcats are coming off a very controversial loss against Rutgers as they lost on a four-point play with seconds remaining but the fact of the matter is that Villanova never should have been in that position in the first place as it blew a 10-point lead with 2:52 remaining. That was the fourth loss in seven games for the Wildcats including their second against an unranked foe. Villanova has lost only once at home this season but it is 1-5 ATS in its last six games following a loss.

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